Antibiotics and Pregnancy. What Mothers Should Know
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The transport of drugs is governed by diffusion, surface area available for transfer, lipid solubility, molecular weight, degree of ionization, partition coefficient, and maternal-fetal concentration gradient. The availability of a drug for transport is dependent, in turn, on the binding of the drug to the plasma proteins. Forming a drug-protein complex is contingent upon covalent and ionic bonding between polar and nonpolar groups on the antibiotic and upon the polarity of amino acids available for binding. The unbound fraction in the serum is pharmacologically active and in a state of dynamic equilibrium with the drug present in the extra-cellular space. As free drug is excreted
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Article Title: Antibiotics and Pregnancy. What Mothers Should Know
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